Why do astrologers say you might lose your job or position when Saturn enters your 12th house?

The 12th House, as per Kalpurush Kundali, is the Zodiac of Pisces (Ruled by Jupiter).

12th House is mysterious like the 8th House and is part of the Moksha Trikona (Salvation Trine).

Despite this, the 12th House is feared as it underlines an important aspect – LOSSES

So, let us list down the main reasons for fearing the 12th House:

We also need to understand the positives linked to the 12th House

Linked to bed pleasures
Linked to Foreign Countries and Hints as Foreign Placements
Linked to spiritual awakening and an essential house for moving Moksha/Salvation

So, we have now got an idea linked to the 12th House.

Saturn – the planet linked to judgment of Karma, when it sits in the 12th House – we can make the following observations

Saturn is a planet of slowness and malefic in many aspects. Owing to this, it does well in the 12th House by negating the negatives of the 12th House
Saturn in the 12th House can be linked to better control of finances, investments for the long term and more thought-out decisions
Saturn brings purpose and thought to the work as it aspects House 3, 6, 9 from the 12th House

Beyond the observations shared from your end, it can be safely stated that the transit is not bad.

Also, if you lose your job (like 10th Lord Saturn going into 12th), the development will be for the best.

Kindly note that the question does not give details, and the answer has been given based on the limited data provided.

Hope this helps

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God Bless!